During the first centuries of Ottoman era the Galata tower was occupied by a detachment of Janissaries, the elite corps of the Turkish Army. In the sisteenth century the tower was used to house prisoners of war, who were usualy consigned as galley slaves in the ottoman arsenal at Kasimpasa on the golden horn.



During the reign of Selim 2nd (1566-1574) the Galata Tower was used as an observation point by the renowed Turkish astronomer Takiuddin, who had his main observatory in Pera. In the following century, during the reign of Mustafa 2nd (1695 - 1703) the seyhulislam Feyzulah efendi tried to set up an astronomical observatory in the tower with with the aid of a Jesuit priest, but the effort was cut short when he was killed in 1703.

The Galata Tower was reconstructed on a number of occasions in the Ottoman period, most notably, after a great fire that destroyed much of Galata in 1794 (during the reign of Selim III) and by Mahmut II in 1832. the tower's conical cap was blown off during a storm in 1875, and it was not replaced in the subsequent restoration. The tower was used as a fire- control station until 1964, when it was closed for restoratiom before being opened in 1967 as a tourist attraction. The conical cap was replaced in this restoration, giving the tower much the same appearance as it had in Genoese times, though retaining the changes in fenestration and other structual aspects done in the Ottoman period.